Dr. Jacob Manjarrez
Postdoctoral Research Associate
Tandy School of Computer Science
University of Tulsa
jrm8361 at utulsa.edu
Educational Background
Ph.D., 2012, Oklahoma State University, Stillwater, OK
The Department of Biochemistry and Molecular Biology
Advisor: Dr. Robert L. Matts
B.S., 2003, Oklahoma State University, Stillwater, OK
Major: Cell and Molecular Biology
Biographical Information
Dr. Jacob Manjarrez is a Postdoctoral Research Associate in the Computational Neuroscience and Adaptive Systems (CNAS) lab, which focuses on the investigation of biological and artificial systems that adapt in order to solve problems. He attends to the day-to-day biological related aspects while conducting the in-depth biological investigations as his main training and focus lies in the study of the Caenorhabditis elegans nervous system.
His interests in the overall functionality of the C. elegans nervous system coupled with his biochemical background has opened the doors to a variety of genetic and chemical manipulation of the nervous system. He has been able to explore many different questions through the utilization of the CNAS lab’s imaging capabilities and adaptive software solutions. He is in charge of training, maintaining and executing imaging related experimentation using the CNAS labs facilities. His major focus is providing the biological framework as the CNAS lab continues to build models of the nervous system to use in the development of next generation control systems as part of an AFOSR grant.
Publications
- Manjarrez, J.R and Mailler, R. (2017) “Time and Stress Constraints of elegans Immobilization Techniques.” In preparation.
- McManus, J.R., Grundahl, K., Frisby, D.L., Mullen, G.P., Manjarrez, J.R., Mathews, E.A., Duke, A., and Rand, J.B. (2017) “The C. elegans RIM-Piccolo Homolog CLA-1 is required for normal synaptic transmission.” Submitted for publication.
- Mathews,E.A., Mullen,G.P., Manjarrez J.R., and Rand, J.B. (2015) “Unusual regulation of splicing of the cholinergic locus in Caenorhabditis elegans.” Genetics, 199:3, 729-37.
- Manjarrez, J. R., Sun, L., Prince, T., & Matts, R. L. (2014). “Hsp90-dependent assembly of the DBC2/RhoBTB2-cullin3 E3-ligase complex.” PLoS ONE, 9(3).
- Sun, L., Prince, T., Manjarrez, J.R., Scroggins, B.T., and Matts, R.L. (2012) “Characterization of the interaction of Aha1 with components of the Hsp90 chaperone machine and client proteins.” Biochim Biophys Acta.1823:6, 1092-1101.
- Davenport, J., Manjarrez, J.R., Peterson, L., Krumm, B., Blagg, B.S.J., and Matts, R.L. (2011) “Gambogic Acid, a Natural Product Inhibitor of Hsp90.” J Nat Prod.74:5, 1085-1092.
- Eskew, J., Duren, A., Zhang, X., Morales, P., Swink, M., Dunwiddie, I., Donnelly, A., Tanol, M., Rajewski, R., Manjarrez, , Matts, R., Holzbeierlein, J., and Vielhauer, G. (2011) “Development and characterization of a novel C-terminal inhibitor of Hsp90 in androgen dependent and independent prostate cancer cells.” BMC Cancer. Oct 31:11, 468-483.
- Matts, R.L., and Manjarrez, J. (2009) “Assays for identification of Hsp90 inhibitors and biochemical methods for discriminating their mechanism of action.” Current topics in Medicinal Chemistry, 9:15, 1462-1478.
- Tucker, K.R., Jacobs, D., Manjarrez, J., and John, G.H. (2006) “The metabolism of phenobarbital, a drug used for epilepsy, by intestinal flora, Bifidobacterium adolescentis and Bifidobacterium bifidum.” Microb Ecol Health and Disease, 18:1, 32-37.